From I-75, Take Us-301 To The West. The Entrance To Sanctuary Cove Will Be To Your Left, At The Light Of 16Th Ave E, Across From Detwiler's. From Us-301 N, Take 10Th E To The East. The Entrance To Sanctuary Cove Will Be To Your Right, At The Light Of 16Th Ave E. The Entrance Will Be At The Second Gate, After Passing The Mailboxes.