Take Manatee Avenue And Follow Signs For Holmes Beach/Anna Maria Island. Continue Onto Gulf Drive N: Once You're On Anna Maria Island, Manatee Avenue Will Merge Into Gulf Drive N. Continue Straight On Gulf Drive N. Turn Left Onto 6Th Street: When You Reach 6Th Street, Turn Left. This Should Be After Passing Through Holmes Beach City Area. Arrive At 105 6Th Street: Drive Along 6Th Street Until You Arrive At 105. The Destination Will Be On Your Left Or Right, Depending On Your Direction Of Travel.